Ozempic and similar weight-loss drugs have become Hollywood's worst-kept secret, with celebrities from billionaires to reality stars admitting they've used the medications to slim down.
The injectable drug — originally developed to treat Type 2 diabetes — works by mimicking a hormone that targets areas of the brain that regulate appetite and food intake.
While many stars have been suspected of using Ozempic, Wegovy or Mounjaro to achieve dramatic weight loss, only a handful have spoken out about their experiences.
Here are all the famous faces who've admitted to using Ozempic and similar drugs.
Elon Musk
The Tesla and SpaceX CEO credited Ozempic and Wegovy for his slimmed-down physique after he posted a shirtless photo in 2022.
Musk's admission was one of the first high-profile celebrity endorsements of the drug for weight loss.
Oprah Winfrey
The media mogul revealed in December 2024 that she uses a weight-loss drug but didn't specify which one.
Winfrey has been vocal about her decades-long weight loss journey and said the medication helped her break through a plateau.
Video: Meghan Trainor, Oprah and other celebrities who've admitted to using Ozempic (4:03)
Amy Schumer
The comedian and actress admitted to using Ozempic but said she eventually stopped due to the side effects.
Schumer said she lost weight on the drug but decided it wasn't worth the negative effects on her quality of life.
Full List of Celebrities Who've Admitted to Using Weight-Loss Drugs
Controversy and Shortages
The trend has sparked debate about the accessibility of the drug, with shortages reported for diabetics who rely on it for medical reasons.
Many doctors have expressed concern that the off-label use of diabetes medications for cosmetic weight loss could limit access for patients who need them to manage their health conditions.
As more celebrities come forward, the conversation around weight-loss drugs continues to evolve, with discussions about appropriate use, insurance coverage, and long-term effects.
Side Effects and Considerations
While Ozempic and similar drugs have shown remarkable effectiveness for weight loss, they come with potential side effects including nausea, vomiting, diarrhea, and in rare cases, more serious complications.
Experts recommend that anyone considering these drugs consult with a healthcare provider to discuss whether they're appropriate and to monitor for potential side effects.
The drugs are typically prescribed alongside diet and exercise changes for sustainable weight management.
